Martha M. Murray, Professor of Orthopaedic Surgery at Harvard Medical School

Martha M. Murray, Professor of Orthopaedic Surgery at Harvard Medical School

  • Alternate Email Address:
  • sports.medicine@childrens.harvard.edu
  • Country:
  • United States
  • Postal Code:
  • 02115
  • Phone:
  • 617-355-7132
Biography:

Please note that Dr Murray does not endorse any of the products that are linked to these pages. These links are placed there by advertisers, not by Dr Murray. If you are considering having any surgical procedure, please google "pubmed" (a free website to read medical papers) or ask your surgeon for the published trials of the results of that technique before you have surgery. You can also see if your US surgeon has a known financial connection to any orthopedic device company by googling "payments to doctors" and typing in their name on the Open Payments system. If you would like information about the BEAR technique for ACL surgery, please visit http://www.childrenshospital.org/aclbeartrial or email us at bear.trial@childrens.harvard.edu. Boston Children's Hospital is currently the only location where this surgery is performed.

Bibliography:

Research Investigations:
1. Murray MM, Spector M. Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: The presence of -smooth muscle actin-positive cells. J Orthop Res 1999 Jan; 17:18-26.http://www.ncbi.nlm.nih.gov/pubmed/10073643
2. Murray MM, Martin SD, Spector M. The migration of cells from human anterior cruciate ligament explants into three dimensional collagen-glycosaminoglycan scaffolds in vitro. J Orthop Res 2000 Jul; 18(4): 557-64.http://www.ncbi.nlm.nih.gov/pubmed/11052491
3. Qiu W, Murray MM, Shortkroff S, Lee CR, Martin SD, Spector M. Outgrowth of chondrocytes from human articular cartilage explants and expression of -smooth muscle actin. Wound Repair and Regeneration 2000 Sep-Oct; 18 (5):383-391. https://www.ncbi.nlm.nih.gov/pubmed/11115150
4. Murray MM, Martin SD, Martin TL, Spector M. Histologic changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am, 2000; 82A(10):1387-1397. https://www.ncbi.nlm.nih.gov/pubmed/11057466
5. Premdas J, Tang JB, Warner JP, Murray MM, Spector M. The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. J Orthop Res, 2001 Mar; 19(2): 221-228. https://www.ncbi.nlm.nih.gov/pubmed/11347694
6. Ahluwalia S, Fehm M, Murray MM, Martin SD, Spector M. Distribution of smooth muscle actin-containing cells in the human meniscus. J Orthop Res, 2001 Jul; 19(4): 649-654. https://www.ncbi.nlm.nih.gov/pubmed/11518276
7. Murray MM, Spector M. The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. Biomaterials 2001 Sep; 22:2393-2402. https://www.ncbi.nlm.nih.gov/pubmed/11511036
8. Murray MM, Bennett RL, Spector MS. Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-1. J Orthop Res 2002 Jul; 20:875-880. https://www.ncbi.nlm.nih.gov/pubmed/12168681
9. Spindler KP, Murray MM, Detwiler KB, Tarter JT, Dawson JM, Davidson JM. The biomechanical response to doses of TGF-b2 in the healing rabbit medial collateral ligament. J Orthop Res, 2003 Mar; 21(2): 245-249. https://www.ncbi.nlm.nih.gov/pubmed/12568955
10. Murray MM, Rice K, Wright RJ, Spector M. The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three dimensional collagen-GAG scaffold. J Orthop Res, 2003 Mar; 21(2):238-44. http://www.ncbi.nlm.nih.gov/pubmed/12568954
11. Murray MM, Zurakowski D, Vrahas MS. The death of articular chondrocytes after intra-articular fracture in humans. Journal of Trauma, 2004 Jan; 56 (1): 128-131. https://www.ncbi.nlm.nih.gov/pubmed/14749579
12. Kolker D, Murray MM, Wilson M. Osteochondral defects of the talus treated with autologous bone grafting. J Bone Joint Surg Br, 2004; 86(4): 521-526. https://www.ncbi.nlm.nih.gov/pubmed/15174546
13. Pascher A, Steinert AF, Palmer GD, Betz O, Gouze JN, Gouze E, Pilapil C, Ghivizzani SC, Evans CH, Murray MM. Enhanced repair of the anterior cruciate ligament by in situ gene transfer: Evaluation in an in vitro model. Molecular Therapy 2004; 10(2): 327-336. https://www.ncbi.nlm.nih.gov/pubmed/15294179
14. Murray MM, Weiler A, Spindler KP. Interspecies variation in the fibroblast distribution of the anterior cruciate ligament. Am. J. Sports Med., 2004; 32:1484-1491. https://www.ncbi.nlm.nih.gov/pubmed/15310575
15. Murray MM, Spindler KP. Anterior cruciate ligament healing and primary repair. Sports Medicine and Arthroscopy Review, 2005; 13(3):151-155.
16. Murray MM, Forsythe B, Chen F, Lee SJ, Yoo JJ, Atala A, Steiner A. The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. J Orthop Res 2006 Mar; 24:508-515. https://www.ncbi.nlm.nih.gov/pubmed/16453341
17. Spindler KP, Murray MM, Devin C, Nanney LB, Davidson JM. The central ACL defect as a model for failure of intra-articular healing. J Orthop Res 2006 Mar; 24:401-406. https://www.ncbi.nlm.nih.gov/pubmed/16479574
18. Murray MM, Spindler KP, Devin C, Snyder BD, Muller J, Takahasi M, Ballard P, Nanney LB, Zurakowski D. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res 2006, 24:820-830. https://www.ncbi.nlm.nih.gov/pubmed/16555312
19. Mahan S, Murray MM, Woolf A, Kasser J. Increased blood lead levels in an adolescent girl from a retained bullet: a case report. J Bone Joint Surg. 2006 Dec; 88(12):2762-9.
20. Murray MM, Spindler KP, Abreu E, Muller J, Nedder A, Kelly M, Frino J, Zurakowski D, Valenza M, Snyder BD, Connolly SA. Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res. 2007 Jan, 25:81-91. https://www.ncbi.nlm.nih.gov/pubmed/17031861
21. Mesiha M, Zurakowski D, Soriano J, Nielson JH, Zarins B, Murray MM. Pathologic characteristics of the torn human meniscus. Am. J. Sports Med. 2007 Jan, 35:103-112. https://www.ncbi.nlm.nih.gov/pubmed/17092929
22. Murray MM, Spindler KP, Ballard P, Welch T, Nanney LB. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res, 2007 Aug; 25(8):1007-1017. https://www.ncbi.nlm.nih.gov/pubmed/17415785
23. Steiner ME, Murray MM, Rodeo SA. Strategies to improve anterior cruciate ligament healing and graft placement. American Journal of Sports Medicine, 2008; Jan;36(1):176-89. https://www.ncbi.nlm.nih.gov/pubmed/18166680
24. Steinert AF, Weber M, Kunz M. Palmer GD, Noth U, Evans CH, Murray MM. In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament. Biomaterials, 2008 Mar; 29(7):904-16. https://www.ncbi.nlm.nih.gov/pubmed/18045683
25. Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM. Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg. 2008 Apr. 66(4):684-90. PMCID: PMC2405953. https://www.ncbi.nlm.nih.gov/pubmed/18355591
26. Jacobson M, Fufa D, Abreu E, Kevy S, Murray MM. Platelets, but not erythrocytes, significantly affect cytokine release and scaffold contraction in a provisional scaffold model. Wound Repair and Regeneration, 2008; May-Jun;16(3):370-8. PMCID: PMC3580948. https://www.ncbi.nlm.nih.gov/pubmed/18471255
27. Fleming BC, Carey J, Spindler KP, Murray MM. Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study. J Orthop Res. 2008 Nov; 26(11):1500-5. PMCID: PMC2790602. https://www.ncbi.nlm.nih.gov/pubmed/18528857
28. Butler DL, Lewis JL, Frank CB, Banes AJ, Caplan AI, DeDeyne PG, Dowling M, Fleming BC, Glowacki J, Guldbery RE, Johnstone B, Kaplan DL, Levenston ME, Lotz JC, Lu EY, Lumelsky N, Mao JJ, Mauck RL, McDevitt CA, Mejia LC, Murray MM, Ratcliffe A, Spindler KP, TashmanS, Wagner CT, Weisberg EM, Williams C, Zhang R. Evaluation criteria for musculoskeletal and craniofacial tissue engineering constructs: A conference report. Tissue Engineering, Tissue Eng Part A. 2008 Dec;14(12):2089-104. https://www.ncbi.nlm.nih.gov/pubmed/19093294
29. Murray MM. Current status and potential of primary ACL repair, Clin Sports Med. 2009 Jan;28(1):51-61. PMCID: PMC2642924. https://www.ncbi.nlm.nih.gov/pubmed/19064165
30. Pearse RV, Esshaki D, Tabin CJ, Murray MM. Genome-wide expression analysis of intra- and extra-articular connective tissue. J Orthop Res. 2009 Apr;27(4):427-34. PMCID: PMC2856484. https://www.ncbi.nlm.nih.gov/pubmed/18972360
31. Murray MM, Palmer M, Abreu E, Spindler KP, Zurakowski D, Fleming BC. Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: An in vivo study. J Ortho Res. 2009 May 27 (5): 639-45. PMCID: PMC2824566. https://www.ncbi.nlm.nih.gov/pubmed/18991345
32. Spindler KP, Murray MM, Carey JL, Zurakowski D, Fleming BC. The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res. 2009 May; 27(5):631-8. PMCID: PMC2752673. https://www.ncbi.nlm.nih.gov/pubmed/19009602
33. Palmer MP, Abreu EL, Mastrangelo A, Murray MM. Injection temperature significantly affects in vitro and in vivo performance of collagen-platelet scaffolds. J Orthop Res. 2009 Jul;27(7):964-71. PMCID: PMC2735874. https://www.ncbi.nlm.nih.gov/pubmed/19030174
34. Fleming BC, Spindler KP, Palmer M, Magarian E, Murray MM. Collagen-platelet composites improve the biomechanical properties of healing ACL grafts in a porcine model. Am J Sports Med, 2009 Aug; 37(8):1554-63. PMCID: PMC2796133. https://www.ncbi.nlm.nih.gov/pubmed/19336614
35. Abreu EL, Palmer MP, Murray MM. Storage conditions do not have detrimental effect on allograft collagen or scaffold performance. Cell Tissue Bank. 2009 Nov; 10(4):333-40 . https://www.ncbi.nlm.nih.gov/pubmed/19507051
36. Joshi SM, Mastrangelo AN, Fleming BC, Murray MM. Collagen-platelet composite enhances biomechanical and histologic healing of the ACL. Am J Sports Med, 2009 Dec; 37(12):2401-10. PMCID: PMC2856313 https://www.ncbi.nlm.nih.gov/pubmed/19940313
37. Kritsaneepaiboon S, Shah R, Murray MM, Kleinman PK. Posterior periosteal disruption in Salter-Harris II fractures of the distal femur: Evidence for a hyperextension mechanism. Am J Roentgenol. 2009 Dec; 193(6): W540-5. https://www.ncbi.nlm.nih.gov/pubmed/19933629
38. Vavken, P, Joshi, S. and Murray, M.M. Triton-X is most effective among three decellularization agents for ACL tissue engineering. J Orthop Res. 2009 Dec;27(12):1612-8. PMCID: PMC2824567 https://www.ncbi.nlm.nih.gov/pubmed/19504590
39. Vavken P, Murray MM. Translational studies in ACL repair. Tissue Eng Part B Rev. 2010 Feb;16(1):5-11. https://www.ncbi.nlm.nih.gov/pubmed/20143926
40. Abreu EL, Palmer MP, Murray MM. Collagen density significantly affects the functional properties of an engineered provisional scaffold .J Biomed Mater Res A. 2010 Apr;93(1):150-7. PMCID: PMC3069635 https://www.ncbi.nlm.nih.gov/pubmed/19536834
41. Cheng MY, Wang H, Yoshida R, Murray MM. Platelets and plasma proteins are both required to stimulate collagen gene expression by ACL cells in three-dimensional culture. Tissue Eng Part A. 2010 May;16(5):1479-89. PMCID: PMC2952126. https://www.ncbi.nlm.nih.gov/pubmed/19958169
42. Mastrangelo AN, Magarian EM, Palmer MP, Murray MM. The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res. 2010 May;28(5):644-51. PMCID: PMC2845722. https://www.ncbi.nlm.nih.gov/pubmed/19890988.
43. Fleming BC, Magarian EM, Harrison SL, Paller DJ, Murray MM. Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament. J Orthop Res, 2010 Jun; 28(6):703-9. PMCID: PMC2858260. https://www.ncbi.nlm.nih.gov/pubmed/20058276
44. Haddad-Weber M, Prager P, Kunz M, Seefried L, Jakob F, Murray MM, Evans CE, Noth U, Steinert AF. BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells. Cytotherapy. 2010 Jul; 12(4):505-13. PMCID: PMC3580941 https://www.ncbi.nlm.nih.gov/pubmed/20334610
45. Mastrangelo AN, Haus B, Vavken P, Murray MM. Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. J Orthop Res. 2010 Aug;28(8):1100-6. PMCID: PMC2892020. https://www.ncbi.nlm.nih.gov/pubmed/20127960
46. Vavken P, Saad FA, Murray MM. Age-dependence of expression of growth factor receptors in porcine ACL fibroblasts. J Orthop Res, 2010 Aug; 28(8):1107-12. PMCID: PMC2892023 https://www.ncbi.nlm.nih.gov/pubmed/20186834
47. Murray MM, Magarian E, Zurakowski D, Fleming BC. Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite.
Arthroscopy. 2010 Sep; 26(9 Suppl):S49-57. PMCID: PMC2936961 https://www.ncbi.nlm.nih.gov/pubmed/20810092
48. Murray MM, Magarian EM, Harrison SL, Zurakowski D, Fleming BC. The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am, 2010 Nov; 92(11): 2039-49. PMCID: PMC2924734. https://www.ncbi.nlm.nih.gov/pubmed/20810854
49. Magarian EM, Fleming BC, Harrison SL, Mastrangelo AN, Badger G, Murray MM. Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine ACL. AJSM, 2010 Dec; 38(12): 2528-34. PMCID: PMC2996471. https://www.ncbi.nlm.nih.gov/pubmed/20855556
50. Vavken P, Joshi SM, Murray MM. Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis. The Knee, 2011, Jan; 18(1):42-6. PMCID: PMC2891311. https://www.ncbi.nlm.nih.gov/pubmed/20080411
51. Harrison S, Vavken P, Kevy S, Jacobson M, Zurakowski D, Murray MM. Platelet activation by collagen provides sustained release of anabolic cytokines. Am J Sports Med. 2011, Apr 39(4):729-34. PMCID: PMC3176726 https://www.ncbi.nlm.nih.gov/pubmed/21398575
52. Vavken P, Murray MM. The potential for primary repair of the ACL. Sports Med Arthroscopy. 2011, Mar;19(1):44-9. PMCID: PMC3073665 https://www.ncbi.nlm.nih.gov/pubmed/21293237
53. Steinert A, Kunz M, Barthel T, Jakob F, Noeth U, Murray MM, Evans C, Porter R. Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Engineering, Part A, 2011, May: 17(9-10):1375-88. PMCID: PMC3079172. https://www.ncbi.nlm.nih.gov/pubmed/21247268
54. Vavken P, Murray MM. Treating anterior cruciate ligament tears in skeletally immature patients. Arthroscopy, 2011 May 1;27(5):704-716. PMCID: PMC3088307 https://www.ncbi.nlm.nih.gov/pubmed/21552340
55. Mastrangelo AN, Vavken P, Fleming BC, Harrison SH, Murray MM. Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model. J Ortho Res, 2011 Jul; 29(7):1002-7. PMCID: PMC3094496. https://www.ncbi.nlm.nih.gov/pubmed/21337615
56. Magarian EM, Vavken P, Murray MM. Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals. Knee. 2011 Aug; 18(4):247-51. PMCID: PMC2991424 https://www.ncbi.nlm.nih.gov/pubmed/20728363
57. Vavken P, Sadoghi P, Murray MM. The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials. Arthroscopy, 2011, 27(11):1573-83. PMCID: PMC3206130. http://www.ncbi.nlm.nih.gov/pubmed/21862277
58. Palmer M., Stanford E, Murray MM. The effect of synovial fluid enzymes on the biodegradability of collagen and fibrin clots. Materials (Basel). 2011 Aug 20;4(8):1469-1482 PMCID: PMC3176731. http://www.ncbi.nlm.nih.gov/pubmed/21949586
59. Harrison SL, Vavken P, Murray MM. Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold. J Orthop Res. 2011 Sep 29(9):1361-6. PMCID: PMC3176723. http://www.ncbi.nlm.nih.gov/pubmed/21445984
60. Vavken P, Saad FA, Fleming BC, Murray MM. VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL. Knee Surg Sports Traumatol Arthrosc. 2011 Oct; 19(10):1675-82. PMCID: PMC3210695. http://www.ncbi.nlm.nih.gov/pubmed/21331648
61. Fleming BC, Vajapeyam S, Connolly S, Magarian EM, Murray MM. The use of magnetic resonance imaging to predict ACL graft structural properties. J Biomechanics, 2011 Nov 10;44(16):2843-6. PMCID: PMC3208804. http://www.ncbi.nlm.nih.gov/pubmed/21962290
62. Cheng M, Johnson V, Murray MM. Effects of age and platelet-rich plasma on ACL cell viability and collagen gene expression. J Orthop Res. 2012 Jan;30(1):79-85. PMCID: PMC3202019. https://www.ncbi.nlm.nih.gov/pubmed/21748791
63. Haus BM, Mastrangelo AN, Murray MM. Effect of anterior cruciate healing on the uninjured ligament insertion site. J Orthop Res, 2012 Jan;30(1):86-94. PMCID: PMC3220740. https://www.ncbi.nlm.nih.gov/pubmed/21748793
64. Vavken P, Fleming BC, Mastrangelo AN, Machan JT, Murray MM. Biomechanical outcomes after bio-enhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model. Arthroscopy, 2012 May; 28(5):672-80. PMCID: PMC334046. http://www.ncbi.nlm.nih.gov/pubmed/22261137
65. Magarian EM, Vavken P, Connolly SA, Mastrangelo AN, Murray MM. Safety of intra-articular use of atelocollagen for enhanced. Tissue Repair. Open Orthopaedics Journal, 2012 May 6, 212-219. PMCID: PMC3395883. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395883/
66. Proffen BL, Fleming BC, Murray MM. A comparative anatomical study of the human knee and six animal species. Knee. 2012 Aug;19(4):493-9. PMCID: PMC3236814. https://www.ncbi.nlm.nih.gov/pubmed/21852139
67. Yoshida R, Vavken P, Murray MM. Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells. Knee. 2012 Oct;19(5):672-5. PMCID: PMC3243811.. http://www.ncbi.nlm.nih.gov/pubmed/21925883
68. Yoshida R, Murray MM. Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts. J Orthop Res. 2013 Jan;31(1):29-34. PMCID: PMC3469725. http://www.ncbi.nlm.nih.gov/pubmed/22767425
69. Vavken P, Proffen B, Peterson C, Fleming BC, Machan JT, Murray MM. Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study. Arthroscopy. 2013 Jan; 29(1):122-32 PMCID: PMC3644616. http://www.ncbi.nlm.nih.gov/pubmed/23200845
70. Biercevicz A, Miranda DL, Machan JT, Murray MM, Fleming BC. In situ non-invasive T2*-weighted MRI derived parameters determine ex vivo structural properties of an ACL reconstruction or bio-enhanced primary repair in a porcine model. Am J Sports Med. 2013 Mar;41(3):560-6. PMCID: PMC3593999. http://www.ncbi.nlm.nih.gov/pubmed/23348076
71. Proffen BL, Haslauer CM, Harris CE, Murray MM. Mesenchymal stem cells from the retropatellar fat pad and peripheral blood stimulate ACL fibroblast migration, proliferation and collagen gene expression. Connect Tissue Res. 2013;54(1):14-21. PMCID: PMC3836054. http://www.ncbi.nlm.nih.gov/pubmed/22839298
72. Murray MM, Fleming BC. Use of a bioactive scaffold to stimulate ACL healing also minimizes post-traumatic osteoarthritis after surgery. Am J Sports Med. 2013 Aug;41(8):1762-70. PMCID: PMC3735821. http://www.ncbi.nlm.nih.gov/pubmed/23857883
73. Rodeo SA, Boden SD, Murray MM, Einhorn TA. 2011 AOA Symposium: tissue engineering and tissue regeneration: AOA critical issues. J Bone Joint Surg Am. 2013 Aug 7;95(15):e109. PMCID: PMC3748991. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748991/
74. Murray MM, Fleming BC. Biology of anterior cruciate ligament injury and repair: Kappa Delta Ann Doner Vaughn award paper 2013. J Orthop Res. 2013 Oct;31(10):1501-6. PMCID: PMC3750083. http://www.ncbi.nlm.nih.gov/pubmed/23818453
75. Proffen BL, Fleming B, Murray MM. Histologic predictors of maximum failure loads differ between the healing ACL and ACL grafts after 6 and 12 months in vivo. J Ortho Sports Med 2013 Nov; 1(6):1-12. PMCID: PMC4203461. http://www.ncbi.nlm.nih.gov/pubmed/25343145
76. Haslauer CM, Elsaid KA, Fleming BC, Proffen BL, Johnson VM, Murray MM. Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury, Osteoarthritis Cartilage. 2013 Dec;21(12):1950-7. PMCID: PMC3917322. http://www.ncbi.nlm.nih.gov/pubmed/24036379
77. Haslauer CM, Proffen BL, Johnson VM, Murray MM. Expression of modulators of extracellular matrix structure after anterior cruciate ligament injury. Wound Repair and Regeneration 2014 Jan-Feb;22(1):103-10. PMCID: PMC3888089. http://www.ncbi.nlm.nih.gov/pubmed/24393158
78. Yoshida R, Cheng M, Murray MM. Increasing platelet concentration in platelet-rich plasma inhibits anterior cruciate ligament cell function in three-dimensional culture, J Orthop Res. 2014 Feb;32(2):291-5 PMCID: PMC3945668. http://www.ncbi.nlm.nih.gov/pubmed/24122902
79. Kiapour AM, Murray MM. Basic science of anterior cruciate ligament injury and repair. Bone and Joint Research. 2014, Feb; 3(2): 20-31. PMCID: PMC3922117 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922117.
80. Biercevicz AM, Murray MM, Walsh EG, Miranda DL, Machan JT, Fleming BC. T2* MR relaxometry to predict healing ligament structural properties. Orthop Res. 2014 Apr;32(4):492-499. PMCID: PMC3946219. http://www.ncbi.nlm.nih.gov/pubmed/24338640
81. Proffen BL, Nielson JH, Zurakowski D, Micheli LJ, Curtis C, Murray MM. The effect of perioperative Ketorolac on the clinical failure rate of meniscal repair. Orthopaedic Journal of Sports Medicine. 2014 May 1. 2(5):1-8. PMCID: PMC4228481. http://www.ncbi.nlm.nih.gov/pubmed/25401118
82. Biercevicz A, Walsh E, Murray MM, Fleming BC. Improving the clinical efficiency of T2* mapping of ligament integrity. Journal of Biomechanics. 2014 Jul 18;47(10):2522-5. PMCID: PMC4057958. http://www.ncbi.nlm.nih.gov/pubmed/24792580
83. Bennike T, Ayturk U, Haslauer C, Froehlich J, Proffen B, Barnaby O, Birkelund S, Murray MM, Warman M, Stensballe A, Steen H. A normative study of the synovial fluid proteome from healthy porcine knee joints. Journal of Proteome Research. 2014 Oct 3; 13(10):4377-87. PMCID: PMC4184458. http://www.ncbi.nlm.nih.gov/pubmed/25160569
84. Haslauer CM, Proffen BL, Johnson VM, Hill A, Murray MM. Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL Injury in a preclinical model. Journal of Inflammation. 2014 Nov 1; 11(1):34. PMCID: PMC4232656. http://www.ncbi.nlm.nih.gov/pubmed/25400511
85. Kiapour AM, Shalvoy MR, Murray MM, Fleming BC. Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders. Clin Orthop Relat Res. 2015 Feb; 473(2):639-50. PMCID: PMC4294889. http://www.ncbi.nlm.nih.gov/pubmed/25269532
86. Proffen BL, Vavken P, Haslauer CM, Fleming BC, Harris CE, Machan JT, Murray MM. Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model. Am J Sports Med. 2015 Feb;43(2):320-30. PMCID: PMC4511104. http://www.ncbi.nlm.nih.gov/pubmed/25549633
87. Hutchinson ID, Rodeo SA, Perrone GS, Murray MM. Can platelet rich plasma enhance ACL and meniscal repair? J Knee Surg. 2015 Feb;28(1):19-28. PMID: 25101873. http://www.ncbi.nlm.nih.gov/pubmed/25101873
88. Proffen BL, Perrone GS, Roberts G, Murray MM. Bridge-enhanced ACL repair: a review of the science and the pathway through FDA investigational device approval. Annals of Biomedical Engineering, 2015 March; (43) 3: 805–818. PMCID: PMC4799652. http://www.ncbi.nlm.nih.gov/pubmed/25631206

89. Fleming BC, Proffen BL, Vavken P, Shalvoy MR, Machan JT, Murray MM. Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2015 Apr;23(4):1161-70. PMCID: PMC4167989. http://www.ncbi.nlm.nih.gov/pubmed/24633008
90. Proffen BL, Sieker JT, Murray MM. Bio-enhanced repair of the anterior cruciate ligament. Arthroscopy. 2015 May; 31(5):990-7. PMCID: PMC4426066. http://www.ncbi.nlm.nih.gov/pubmed/25595694
91. Kiapour AM, Fleming BC, Proffen BL, Murray MM. Sex influences the biomechanical outcomes of anterior cruciate ligament reconstruction in a pre-clinical large animal model. Am J Sports Med. 2015 Jul;43(7):1623-31. PMCID: PMC4490080. http://www.ncbi.nlm.nih.gov/pubmed/25939612
92. Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Badger GJ, Murray MM. Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing. J Orthop Res. 2015 Jul;33(7):1015-23. PMCID: PMC4517185. http://www.ncbi.nlm.nih.gov/pubmed/25676876
93. Kiapour AM, Fleming BC, Murray MM. Biomechanical outcomes of bridge-enhanced anterior cruciate ligament repair are influenced by sex in a preclinical model. Clin Ortho Relat Res. 2015 Aug;473(8):2599-608. PMC4488214. http://www.ncbi.nlm.nih.gov/pubmed/25742916
94. Biercevicz AM, Proffen BL, Murray MM, Walsh EG, Fleming BC. T2 * Relaxometry and volume predict semi-quantitative histological scoring of an ACL bridge-enhanced primary repair in a porcine model. J Orthop Res. 2015 Aug; 33(8):1180-7. PMCID: PMC4497917. http://www.ncbi.nlm.nih.gov/pubmed/25764143
95. Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Murray MM. Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds. J Biomater Appl. 2015 Oct; 30(4):435-49. PMCID: PMC4670802. http://www.ncbi.nlm.nih.gov/pubmed/26088294
96. Kelly BA, Proffen BL, Haslauer CM, Murray MM. Platelets and plasma stimulate sheep rotator cuff tendon tenocytes when cultured in an extracellular matrix scaffold. J Orthop Res. 2016 Apr;34(4):623-629.
PMCID: PMC4814346 http://www.ncbi.nlm.nih.gov/pubmed/26419602
97. Proffen BL, Sieker JT, Murray MM, Akelman MR, Chin KE, Perrone GS, Patel TK, Fleming BC. Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. J Orthop Res. 2016 Jun;34(6):995-1003. PMCID: PMC4882220
http://www.ncbi.nlm.nih.gov/pubmed/26629963
98. Sieker JT, Ayturk UM, Proffen BL, Weissenberger MH, Kiapour AM, Murray MM. Immediate administration of intra-articular triamcinolone acetonide after joint injury modulates molecular outcomes associated with early synovitis. Arthritis Rheumatol. 2016 Jul;68(7):1637-47. PMID:26866935 http://www.ncbi.nlm.nih.gov/pubmed/26866935

99. Chin KE, Karamchedu NP, Patel TK, Badger GJ, Akelman MR, Moore DC, Proffen BL, Murray MM, Fleming BC. Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model. J Biomech. 2016 Oct 3;49(14):3559-63. PMCID: PMC5074884 https://www.ncbi.nlm.nih.gov/pubmed/27594677

100. Murray MM, Flutie BM, Kalish LA, Ecklund K, Fleming BC, Proffen BL, Micheli LJ. The bridge-enhanced anterior cruciate ligament repair (BEAR) procedure: An early feasibility cohort study. Orthop J Sports Med. 2016 Nov 21;4(11):1-11. PMCID: PMC5120682 https://www.ncbi.nlm.nih.gov/pubmed/27900338

101. Beveridge JE, Walsh EG, Murray MM, Fleming BC. Sensitivity of ACL volume and T2∗ relaxation time to magnetic resonance imaging scan conditions. J Biomech. 2017 May 3;56:117-21. doi: 10.1016/j.jbiomech.2017.03.010. PMID:28359570
102. Perrone GS, Proffen BL, Kiapour AM, Sieker JT, Fleming BC, Murray MM. Bench-to-bedside: bridge-enhanced anterior cruciate ligament repair. J Orthop Res. 2017 Jun 13. doi: 10.1002/jor.23632. [Epub ahead of print] Review. PMID: 28608618
103. Kiapour AM, Fleming BC, Murray MM. Structural and anatomic restoration of the anterior cruciate ligament is associated with less cartilage damage one year after surgery. Orthop J Sports Med. 2017 Aug 28;5(8):2325967117723886. doi: 10.1177/2325967117723886. PMID: 28875154
104. Beveridge, J, Machan, J, Walsh, E., Kiapour, A, Karamchedu, N, Chin, K, Proffen, B, Sieker, J, Murray, M and Fleming B. Magnetic resonance measurements of tissue quantity and quality using T2* relaxometry predict temporal changes in the biomechanical properties of the healing ACL J Orthop Res. 2017 Dec 11. doi: 10.1002/jor.23830. [Epub ahead of print] PMID: 29227559
105. Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Murray MM, Fleming BC. Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 Jan;36(1):318-329. doi: 10.1002/jor.23644. Epub 2017 Aug 3. PMID: 28671352
106. Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Fleming BC, Murray MM. Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 Feb 20. doi: 10.1002/jor.23876. [Epub ahead of print] PMID: 29460983

Institution:

Boston Children's Hospital
Harvard Medical School

About The ACL Study Group

The ACL study group was organized 25 years ago by a small group of orthopedic surgeons with a common interest in the anterior cruciate ligament. Today, Dr. John Bergfeld organizes this large international study group that meets every 2 years to exchange information in an informal and friendly atmosphere.